This study provides a valuable mapping of how genomic variation from a large collection of Klebsiella pneumoniae clinical isolates shapes bacterial fitness across 214 conditions. Solid data describe ...

Neuropeptides mediate inter-tissue communication in energy metabolism, yet most remain functionally uncharacterized. Using C. elegans, we uncover a neuropeptide signaling cascade that drives lipid ...

This important study advances the HIV-1 vaccine development field by establishing six humanized immunoglobulin knock-in mouse models to facilitate the design and evaluation of HIV-1 vaccines. The ...

The authors use a modeling approach to examine the effects of local and global perturbations on the electrophysiological properties of astrocytes: their modeling results suggest that local ionic ...

Laboratory of Neural Computation, Institute for Quantitative Biosciences, the University of Tokyo, Tokyo, Japan Department of Life Sciences, Graduate School of Arts and Sciences, the University of ...

Overall, this is an important article that delivers an invaluable community resource. The execution is relatively simple, but the evidence of this resource is solid. The effort invested in generating ...

This important manuscript reports exceptionally preserved, millimeter-scale segmented bilaterian microfossils from the early Cambrian Fortunian Kuanchuanpu Formation in South China. The authors ...

chaining is more likely when the experiences to be integrated are relatively familiar (greater number of exposures) and ordered in a manner that promotes encoding of the associative links that are ...

We used correlative light and focussed ion beam–scanning electron microscopy (FIBSEM) to characterise the ultrastructural organisation of neuromodulatory axons in the upper layers of the adult mouse ...

This important study combines cortex-wide activity imaging and optogenetics to characterize large-scale changes in functional connectivity following administration of the psychedelic DOI, as well as ...

This important study examines the relationship between climatic niche limits and extinction risk across more than 23,000 terrestrial vertebrate species. The large comparative dataset and phylogenetic ...

Diverse combinations of glutamate receptor subunits are expressed across developmental stages and even between adjacent ...