A causative role for Notch signalling is well established in T cell acute lymphoblastic leukaemias (T-ALLs), which have activating mutations in the Notch genes resulting in a constitutively active ...

The evolutionarily conserved Notch signaling pathway is a contact-dependent communication mechanism regulating cell fate, tissue patterning, and cellular metabolism. Beyond canonical NICD-RBPJ ...

Notch signalling is involved in the cell-cell communication process via influencing the patterns of gene expression and differentiation. Notch pathway maintains stem cell populations and regulates ...

The Notch gene was first described and named in the 20th century by the American scientist Dexter J. Colman through the study of the Notch wing mutant in Drosophila melanogaster (1). Subsequently, ...

Nonalcoholic fatty liver disease is a complex condition involving the progression from simple steatosis to inflammation (nonalcoholic steatohepatitis [NASH]) and then to severe fibrosis and ...

γ-Secretase cleavage of the Notch receptor transmembrane domain is a critical signaling event for various cellular processes. Efforts to develop inhibitors of γ-secretase cleavage of the amyloid-β ...

With over 300 million copies sold since 2011, Minecraft is one of the best-selling video games of all time. And with nearly 170 million monthly active users as of 2024, it remains one of the most ...